Skeletal growth after oral administration of demineralized bone matrix

Abstract
Oral administration of bone extracts obtained from bovine demineralized bone matrix to rats has a direct effect on bone metabolism, affecting bone proportions and some markers of bone formation such as bone malate dehydrogenase, serum alkaline phosphatase and serum osteocalcin. Furthermore collagen deposition, bone protein synthesis and nucleic acids content were significantly increased by the treatment.
Keywords:
Bone Matrix/chemistry, Administration, Animals, Biomarkers/analysis, Bone Development/drug effects, Bone and Bones/drug effects/metabolism, Calcium/blood, Caseins/pharmacology, Cattle, Collagen/analysis, Extracellular Matrix Proteins/administration and dosage/pharmacology, Growth Substances/administration and dosage/isolation and purification/pharmacology, L-Lactate Dehydrogenase/blood, Malate Dehydrogenase/analysis, Male, Maxilla/chemistry, Nucleic Acids/biosynthesis, Oral, Organ Size/drug effects, Osteocalcin/blood, Phosphorus/blood, Pilot Projects, Protein Biosynthesis, Rats, Tissue Extracts/administration and dosage/pharmacology, Wistar, Bone extracts, Bone growth
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