Electroencephalographic study of naloxone effects in the recovery of an acute alcoholic intoxication

M.S. Dawid-Milner
E.J. Díaz-Calavia
J.P. Lara
R. del Moral
J. Jiménez-Vargas
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Abstract

Experimental assays analysing EEG changes during the recovery of an acute alcoholic intoxication were carried out in three groups of cats: 1) Recovery of acute alcoholic intoxication produced by continuous intravenous perfusion of ethanol, 0.06 g/kg/min, during 20 minutes.2) Recovery of acute alcoholic intoxication by injecting naloxone (400 micrograms/kg), just after finishing alcohol perfusion.3) Recovery of acute alcoholic intoxication by injecting naloxone (400 micrograms/kg), 15 min after finishing perfusion.Naloxone administered after an acute alcoholic intoxication worsens the recovery of EEG parameters; 1-2 (p less than 0.05), 1-03 (p less than 0.05).

Keywords:
Alcoholic Intoxication/physiopathology, Animals, Brain/drug effects, Cats, Drug Synergism, Electroencephalography, Endorphins/metabolism, Ethanol/toxicity, Naloxone/pharmacology, Opioid, Opioid/drug effects, Receptors, mu, EEG

Authors

M.S. Dawid-Milner
E.J. Díaz-Calavia
J.P. Lara
R. del Moral
J. Jiménez-Vargas


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