Contribution to the study of the hypoglycemic action of 3-amino-methylbenolsulfonylcyclohexyl carbamide

Abstract

We study the action which 3-amino-4-methylbenzolsulfonil- ciclohexilcarbamide has over the carbohydrate exchange whengiven orally and rectally to normal and diabetic dogs.

The drug is administered at doses of 15 mg per Kg of weight. The blood samples were taken four, six and eight hours after the administration of the drug.

In normal animáis (Graphic 1, Tables I and II) four hours after the administration of the drug, the hypoglycemic effect is greater in the rectally over the orally treated, being it the opposite after six hours and practically equal after eight hours.

In the aloxanized animáis (Graphic 2, Tables III and IV), the hypoglycemic action is clearly superior orally over the rectal administration and with an action superior to that obtai- ned with other drugs previously tested by us in other works.

In the pancreatectomized animáis (Graphic 3, Table V), we have not been able to change the hyperglycemia, due to the extirpation, with this new product.