Metabolic studies with ZINC-65. IV. Data on uptake of this isotope by the blood elements of the dog

Abstract

It is shown the way in which the Zn-65 is taken up by the different components of the blood, when the dog is submitted to weak, continuous inoculations of this isotope. A study is made of the figures attained in total blood, cells, plasma and serum, while the inoculations are going on and when they have finished, up to the end of the 180 days at which this part of the experi- ment finished, for three different total doses.

It has been found (Figs. 2, 3 and 4) that, during the first minutes, all the Zn-65 in the blood is in the serum, the figures for the cells being very low- After 15 minutes, this latter value ascends, which is then superior to that for the serum at all times. The curves of serum and plasma are practically coincident, which indicates that the fibrinogen does not contain Zn-65.

As a first guide to the localization of Zn-65 in the dog, while the animal is alive and on the topographical plan of the same, measurements have been made in mr/h of the radiations emitted by the different organs, it being possible to admit 6 zones with different doses of radiation, and the organs which are preeminently haematopoietic (liver, spleen, etc.) are included in one of the zones of greatest intensity of radiation.