Effects of the pre-incubation in a Na + -free medium on the O 2 uptake and glucose utilization by the intestine

Abstract
The influence of preincubation in a Na+-free medium (mannitol substituting for Na) on the respiratory activity of in testine strips, measured during subsequent incubation in a Na+restored medium, was evaluated. In the absence of glucose, O2 uptake was inhibited. In the presence of glucose, O2 uptake and glucose utilization were inhibited, and similar amount of lactate was produced. The lactate/glucose ratio in the strips preincubated in the Na+-free medium was higher than in the strips preincubated with Na4-. These results further support the evidence that the absence of Na+ during one hour preincu bation disrupts the respiratory capacity of the tissue.
Keywords:
Intestinal Absorption, Oxygen Consumption, Animals, Female, Glucose/metabolism, Intestinal Mucosa/metabolism, Intestine, Male, Rats, Small/metabolism
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