Effects of tromexan on cellular respiration and glucose consumpion

Abstract

Effects of Tromexan on Cellular Respiration and Glucose Consumption

The effects of tromexan on cellular respiration and glucose uptake of yeast, rat diaphragm and liver homogenates have been studied.

At 3.6 X 10-4 M concentration, the drug produces a stimulation of the endogenous respiration and a weak inhibition of exogenous respiration, with an increase in the intake of glucose. In the rat dia­ phragm, the same concentration produces a marked inhibition of both endogenous and exogenous respiration, but the latter case exhibits an increase of educose utilization. Finally, tromexan inhibits the oxygen uptake of homogenized rat liver at concentrations as low as 3 X 10-6 M, with an increase in inhibition, on increasing the concentration.

It is suggest that these effects could be due to the uncoupling of oxidative phosphorylation, which in intact cells would provoke a compensatory action by increasing aerobio glycolysis.