The effect of dicumarol on the active transport, diffusion and oxygen consumption of intestinal sacs

Abstract

This work includes the investigation of the effect of dicumarol on the active trans­ port, diffusion and oxygen uptake of intestinal sacs. The results indicate that dicumarol, 10-s M and 5 X 10-i M, when added to the mucosal fluid, inhibits the active transport of galactose from the mucosal to the serosal fluids and inhibits oxygen uptake in the tissue.
If dicumarol were initially present only in the serosal fluid, it had no influence on the galactose transfer.
It was observed that dicumarol directly hastens the arabinose transference from the mucosal to the serosal fluid (arabinose being initialy present only in the mucosal fluid).

The urea transfer is basically constant, independent of the presence or absence of a 10-5 M dicumarol concentration in the mucosal fluid.

The active transport of galactose from solutions without dicumarol, in inhibited following a 30 minutes preincubation with 5 X 10-5 M dicumarol.