Interference of Cd++ on the turnover of zinc orally administered

Abstract

Results of zinc distribution rates orally administrated to guinea pig and influence on its turnover by Cd++ are given. No biological function for cadmium has been found yet, althought the metalotioneine from kidney with fixed contents of zinc and cadmium has been isolated. The higher affinity of this cation for the thiol groups of a number of enzymes containing zinc appears to be responsible for its toxicity even in very small quantities.

Exponential functions representig variations of zinc distribution has been determined. Cadmium ions disturb the zinc metabolism causing a delay in its assimilation. A competition between Zn++ and Cd++ can be admitted, taking corresponding to the 60th day.