Effect of the ionic environment and of various neurotransmitters on spontaneous motility in snail intestine

A. Barber
R. Jordana
F. Ponz
58

Abstract

A spontaneous rhythmic motility of the isolated intestine in snail, Chryptomphalus hortensis, has been registered at 30 degrees C with the aid of an electronic transductor and an appropriate amplification. These slow regular movements are affected by ionic composition changes in the suspension medium. Na+, K+ and Ca++ ions prove to be important in this motility, and the addition of Ba++ markedly stimulates it. ACh produces hypermotility from 1.8 X 10(-11) g/ml. Its effect decreases in the presence of atropine and increases in that of pyridostigmine. The intestine is sensitive to 5-HT from 10(-10) g/ml, which stimulates its activity. The effect of histamine is weak. Low concentrations of adrenaline tend to increase the amplitude, whereas concentrations from 10(-5) g/ml onward produce a cease of motility in relaxation.

Keywords:
Animals, Barium/pharmacology, Chemical, Electrolytes/pharmacology, Gastrointestinal Motility/drug effects, Intestines/physiology, Ions, Magnesium/pharmacology, Neurotransmitter Agents/pharmacology, Osmolar Concentration, Snails/physiology, Stimulation

Authors

A. Barber
R. Jordana
F. Ponz


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