Serotoninergic mechanisms in ovarian cycle

Abstract

Influence of 5-HT on the rat follicle rupture mechanism was studied by the administration of p-clorophenyl-alanine (p-CPA) (300 mg/kg) at different stages of the ovarian cycle. The ovarian cycle of treated rats was subject of investigation, as well as the histology of tubes and ovaries. Administration of p-CPA at 10 hours of metestrus phase induces an inhibition of ovulation. Predominant diestrus phases in the ovarian cycle and luteinitation of ovaries suggested an increase in progesterone secretion probably owed to a correspondingly greater prolactine secretion. Adequate 5-HT levels in central structures proved to necessary for normal ovulation.