Experimental evaluation of antianginal drugs

J. Esplugues
E. Morcillo
A. Badía
A. Giraldez
R. Bello
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Abstract

A technique for testing antianginal drugs has been developed measuring hemodynamic variables, such as heart rate, left ventricular pressure and its dp/dt, aortic root and coronary sinus pressure, Veragut's index and area under the curve of LVP and metabolic variables, such as A-V difference of oxygen and lactate, oxygen content in coronary sinus, percentage extraction of oxygen, excess lactate. Physiological experimental conditions included spontaneously breathing dogs, catheters introduced under X-rays control and closed chest. A commentary about activity criteria, usefulness and inconvenients of this technique is presented.

Keywords:
Angina Pectoris/diagnosis/drug therapy, Animals, Dogs, Drug Evaluation, Hemodynamics/drug effects, Preclinical, Vasodilator Agents/therapeutic use

Authors

J. Esplugues
E. Morcillo
A. Badía
A. Giraldez
R. Bello


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