Effect of 20-Metylcholanthrene on Diethylnitrosamine-induced Carcinogénesis of Liver
L. Ceballos
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G. Herranz
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Published:
Apr 1, 1970
How to Cite
Ceballos, L., & Herranz, G. (1970). Effect of 20-Metylcholanthrene on Diethylnitrosamine-induced Carcinogénesis of Liver. Revista De Medicina De La Universidad De Navarra, 14(2), 87-102. https://doi.org/10.15581/021.6549
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Authors
L. Ceballos
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G. Herranz
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Abstract
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20-Methylcholanthrene (10 mg/Kg animal weight) and diethylnitrosamine (10 mg/Kg animal weight) were simultaneously administered to rats six days a week. The liver was studied by light and electron microscopy after 4 to 17 weeks of treatment.
When the morphological findings in this experimental group are compared with those observed by us in animals receiving diethylnitrosamine alone, a marked delay in the appearance of the features of the carcinogenic pattern is found. The differences are not of a qualitative nature, but simply quantitative in character, things happening as if a smaller daily dose of diethylnitrosamine were administered.
These findings correlate well with those of other authors studying the inhibitory effect of 20-methylcholanthrene on liver carcinogenesis induced by other chemical carcinogens.
When the morphological findings in this experimental group are compared with those observed by us in animals receiving diethylnitrosamine alone, a marked delay in the appearance of the features of the carcinogenic pattern is found. The differences are not of a qualitative nature, but simply quantitative in character, things happening as if a smaller daily dose of diethylnitrosamine were administered.
These findings correlate well with those of other authors studying the inhibitory effect of 20-methylcholanthrene on liver carcinogenesis induced by other chemical carcinogens.
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