Repartitioning effect of a mixed beta-agonist on body composition

M.P. Portillo; J.A. Martínez; J. Larralde

M.P. Portillo

J.A. Martínez

J. Larralde

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Published: 1990-06-01

Keywords:

Adrenergic beta-Agonists/pharmacokinetics/pharmacology, Animals, Blood Glucose/metabolism, Body Composition/drug effects, Body Weight/drug effects, Carboxypeptidases/metabolism, Cathepsin A, Cathepsins/metabolism, Eating/drug effects, Growth/drug effects, Inbred Strains, Lactates/blood/metabolism, Lactic Acid, Male, Metaproterenol/pharmacokinetics/pharmacology, Muscles/drug effects/enzymology, Oxidation-Reduction, Proteins/metabolism, Pyruvates/blood/metabolism, Pyruvic Acid, Rats

How to Cite

Repartitioning effect of a mixed beta-agonist on body composition. (1990). Revista Española De Fisiología, 46(2), 191-196. https://revistas.unav.edu/index.php/ref/article/view/46297

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Abstract

Subcutaneous administration of a mixed beta-agonist to young rats induced no changes in animal growth and food conversion efficiency. However, a repartitioning effect was found with increases in lean tissue and decreases in body fat. The enhancement of muscle protein deposition was attributed to a fall in protein breakdown as muscular cathepsin A activity was lower in treated rats. A reduction of muscle reduction-oxidation state is associated to those changes in protein metabolism.

Keywords:

Adrenergic beta-Agonists/pharmacokinetics/pharmacology, Animals, Blood Glucose/metabolism, Body Composition/drug effects, Body Weight/drug effects, Carboxypeptidases/metabolism, Cathepsin A, Cathepsins/metabolism, Eating/drug effects, Growth/drug effects, Inbred Strains, Lactates/blood/metabolism, Lactic Acid, Male, Metaproterenol/pharmacokinetics/pharmacology, Muscles/drug effects/enzymology, Oxidation-Reduction, Proteins/metabolism, Pyruvates/blood/metabolism, Pyruvic Acid, Rats