Role of calcium in the phloretin effects on sugar transport in rat small intestine
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15)
Published:
1986-03-01
Keywords:
Animals, Biological Transport/drug effects, Calcium/physiology, Calmodulin/antagonists and inhibitors/physiology, Galactose/metabolism, Imines/pharmacology, Inbred Strains, Intestine, Ion Channels/drug effects/metabolism, Male, Phloretin/pharmacology, Rats, Small/drug effects/metabolism, Trifluoperazine/pharmacology, Verapamil/pharmacology
How to Cite
Role of calcium in the phloretin effects on sugar transport in rat small intestine. (1986). Revista Española De Fisiología, 42(1), 23-28. https://revistas.unav.edu/index.php/ref/article/view/46543
42
Abstract
The effect of phloretin on D-galactose transport in rat small intestine has been investigated.Phloretin enhanced tissue sugar accumulation and reduced mucosal to serosal D-galactose fluxes.Calcium-deprived bathing solutions and verapamil significantly reduced, but did not abolish, the phloretin-effects on intestinal galactose transport.Furthermore in the presence of the anticalmodulin drugs, RMI 12330A and trifluoperazine, phloretin was without effect on D-galactose transport.These findings suggest that phloretin may reduce serosal sugar permeability via an increase in Ca2+-calmodulin complex.
Keywords:
Animals, Biological Transport/drug effects, Calcium/physiology, Calmodulin/antagonists and inhibitors/physiology, Galactose/metabolism, Imines/pharmacology, Inbred Strains, Intestine, Ion Channels/drug effects/metabolism, Male, Phloretin/pharmacology, Rats, Small/drug effects/metabolism, Trifluoperazine/pharmacology, Verapamil/pharmacology
Authors
A.I. Alcalde
Y. Barcina
J. Larralde
A. Ilundain
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