IC50 of trifluoperazine and RMI 12330A for the theophylline and phloretin-induced increase in intestinal D-galactose accumulation
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29)
Published:
1987-09-01
Keywords:
Animals, Calcium/metabolism, Galactose/metabolism, Ileum/metabolism, Imines/pharmacology, In Vitro Techniques, Inbred Strains, Intestinal Absorption/drug effects, Intestinal Mucosa/drug effects/metabolism, Male, Phloretin/antagonists and inhibitors, Rats, Theophylline/antagonists and inhibitors, Trifluoperazine/pharmacology
How to Cite
IC50 of trifluoperazine and RMI 12330A for the theophylline and phloretin-induced increase in intestinal D-galactose accumulation. (1987). Revista Española De Fisiología, 43(3), 371-374. https://revistas.unav.edu/index.php/ref/article/view/46545
78
Abstract
The effect of trifluoperazine and RMI 12330A on D-Galactose accumulation was studied in isolated rat intestinal mucosa.Both drugs inhibited the theophylline and phloretin-induced increase in tissue sugar accumulation in a concentration-dependent fashion, with IC50 values close to 10(-06) M.These findings suggest that calmodulin might mediate the theophylline and phloretin actions on galactose transport in intact rat ileum.
Keywords:
Animals, Calcium/metabolism, Galactose/metabolism, Ileum/metabolism, Imines/pharmacology, In Vitro Techniques, Inbred Strains, Intestinal Absorption/drug effects, Intestinal Mucosa/drug effects/metabolism, Male, Phloretin/antagonists and inhibitors, Rats, Theophylline/antagonists and inhibitors, Trifluoperazine/pharmacology
Authors
A.I. Alcalde
Y. Barcina
J. Larralde
A. Ilundain
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