Angiotensin II increases MAO activity in rat central nervous system

B.E. Fernández; A.E. Domínguez

B.E. Fernández

A.E. Domínguez

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Published: 1991-03-01

Keywords:

Angiotensin II/metabolism/pharmacology, Animals, Blood Pressure/physiology, Chemical, Child, Humans, Hypothalamus/drug effects/enzymology, Inbred Strains, Medulla Oblongata/drug effects/enzymology, Monoamine Oxidase/metabolism, Nephrectomy, Nerve Tissue Proteins/metabolism, Norepinephrine/metabolism, Rats, Renin-Angiotensin System/physiology, Stimulation, MAO, Norepinephrine

How to Cite

Angiotensin II increases MAO activity in rat central nervous system. (1991). Revista Española De Fisiología, 47(1), 37-40. https://revistas.unav.edu/index.php/ref/article/view/46328

41

Abstract

The effects of angiotensin II (ANG II) and bilateral nephrectomy on monoamine oxidase (MAO) activity were studied in rat hypothalamus and medulla oblongata. ANG II increased MAO activity in both central nervous system (CNS) regions. The fall of circulating ANG II caused by 48 h bilateral nephrectomy decreased the activity of the enzyme in the mentioned areas. The results showed that ANG II stimulates catecholamine metabolism in the CNS.

Keywords:

Angiotensin II/metabolism/pharmacology, Animals, Blood Pressure/physiology, Chemical, Child, Humans, Hypothalamus/drug effects/enzymology, Inbred Strains, Medulla Oblongata/drug effects/enzymology, Monoamine Oxidase/metabolism, Nephrectomy, Nerve Tissue Proteins/metabolism, Norepinephrine/metabolism, Rats, Renin-Angiotensin System/physiology, Stimulation, MAO, Norepinephrine

Authors

B.E. Fernández

Facultad de Farmacia y Bioquímica. Junin 956, 7°, Buenos Aires 1113 (Argentina)

https://orcid.org/0000-0002-1825-0097

A.E. Domínguez

Departamento de Ciencias Biológicas, Cátedras de Fisiología y Fisiopatología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires 1113 (Argentina)

https://orcid.org/0000-0002-1825-0097