Normal puberty onset in female rats treated with antiprogesterone RU486 during juvenile period

E. Trimiño
E. Aguilar
61

Abstract

The significance of the increased progesterone plasma levels after day 21 on the onset of puberty in female rats is unclear. To analyze this question, female rats were injected from day 21 to 32 with the potent antiprogestagen RU486 (1 mg/day) or vehicle. Treatment with RU486 did not modify either the age at which vaginal opening or first estrus occurs. Vaginal cycles were regular. Animals sacrificed on day 40 or 50 showed reduced uterus weight, whereas body, pituitary, adrenal and ovaries were not affected. These results evidence that antagonization of progesterone action during the juvenile phase did not affect the onset of puberty.

Keywords:
Animals, Estradiol/blood, Estrus/drug effects, Female, Mifepristone/pharmacology, Organ Size/drug effects, Ovary/drug effects, Progesterone/blood, Rats/physiology, Sexual Maturation/drug effects, Uterus/anatomy and histology/drug effects, Vagina/drug effects

Authors

E. Trimiño
E. Aguilar


Metrics

Search GoogleScholar



Downloads

Download data is not yet available.

Section

Articles

Most read articles by the same author(s)