Effect of secretion on vagal stimulation-evoked exocrine pancreatic secretion in the rat

D. Wisdom
J. Singh
P.J. Camello
J.A. Pariente
G.M. Salido
76

Abstract

The effect of secretin on nerve-mediated pancreatic juice secretion in the anaesthetized rat has been studied. Vagotomy caused a significant reduction in the rate of pancreatic juice flow, total protein output and amylase secretion being compared to control values prior to vagotomy. Both secretin (intravenous infusion 10(-10) mol/kg body weight/h) and electrical stimulation of the vagus nerves (4 V, 2 ms, 20 Hz) caused marked increases in flow, total protein output and amylase output. Pretreatment of rats with atropine (0.1 mg/kg body weight) abolished the electrical stimulation-evoked secretion. However, simultaneous intravenous infusion of secretin and electrical stimulation did not yield either a clear additive response or a potentiation of secretory responses.

Keywords:
Amylases/metabolism, Anesthesia, Animals, Electric Stimulation, Female, Male, Pancreas/metabolism/physiology, Pancreatic Juice/metabolism, Rats, Secretin/physiology, Secretory Rate/physiology, Vagotomy, Vagus Nerve/physiology, Wistar/physiology, Vagus, Exocrine pancreatic secretion

Authors

D. Wisdom
J. Singh
P.J. Camello
J.A. Pariente
G.M. Salido


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