Lipogenic activities in rat liver are subjected to circadian rhythms

R. Zardoya
A. Diez
M.C. Serradilla
J.A. Madrid
J.M. Bautista
A. Garrido-Pertierra
61

Abstract

Diurnal variations were investigated in the activities of the key lipogenic enzymes in rat liver under standard experimental conditions. Fatty acid synthetase, acetyl-CoA-carboxylase, and ATP-citrate lyase showed sinusoidal circadian rhythms (statistically sustained), reaching maximum activity at night and minimum during the light period, with a fold increase value of 1.7, 2.2 and 3.2, respectively. Although a non-sinusoidal circadian rhythm was observed in the malic enzyme activity, statistically different time-dependent activity values were detected throughout a day. The observed rhythms run in parallel with that previously reported for glucose-6-phosphate dehydrogenase, suggesting a whole circadian regulation for rat liver lipogenesis.

Keywords:
ATP Citrate (pro-S)-Lyase/metabolism, Acetyl-CoA Carboxylase/metabolism, Animals, Circadian Rhythm/physiology, Fatty Acid Synthases/metabolism, Lipids/biosynthesis, Liver/enzymology, Malate Dehydrogenase/metabolism, Male, Rats, Time Factors, Wistar/physiology, Lipogenesis, ATP-citrate lyase, Malic enzyme

Authors

R. Zardoya
A. Diez
M.C. Serradilla
J.A. Madrid
J.M. Bautista
A. Garrido-Pertierra


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