Acute peripheral catecholaminergic changes in rat after MPTP and MPP+ treatment

S. Ambrosio; N. Mahy

S. Ambrosio

N. Mahy

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Published: 1989-06-01

Keywords:

1-Methyl-4-phenyl-1, 1-Methyl-4-phenylpyridinium, 2, 3, 6-tetrahydropyridine, Adrenal Medulla/analysis/drug effects, Animals, Heart/drug effects, Inbred Strains, Male, Myocardium/analysis, Norepinephrine/analysis, Pargyline/pharmacology, Pyridines/pharmacology/toxicity, Pyridinium Compounds/pharmacology/toxicity, Rats, Tyrosine 3-Monooxygenase/analysis, MPTP, MPP, Heart, Noradrenaline, Adrenal catecholamines, Pargyline, Tyrosine hydroxylase

How to Cite

Acute peripheral catecholaminergic changes in rat after MPTP and MPP+ treatment. (1989). Revista Española De Fisiología, 45(2), 157-161. https://revistas.unav.edu/index.php/ref/article/view/46564

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Abstract

The effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its main metabolite 1-methyl-4-phenylpyridinium ion (MPP+) on the peripheral catecholaminergic system of the rat were investigated.MPTP and MPP+ injections (20 mg/kg i.p.) caused a marked acute depletion of heart noradrenaline, up to 75% twelve hours after the administration, and a decrease of adrenal gland adrenaline.The time-course of the effect of MPTP and MPP+ is reported, together with a decrease in the tyrosine hydroxylase activity after MPTP treatment, more evident in the adrenal glands.Pargyline (50 mg/kg i.p.) is not able to prevent such a neurotoxic peripheral effect.

Keywords:

1-Methyl-4-phenyl-1, 1-Methyl-4-phenylpyridinium, 2, 3, 6-tetrahydropyridine, Adrenal Medulla/analysis/drug effects, Animals, Heart/drug effects, Inbred Strains, Male, Myocardium/analysis, Norepinephrine/analysis, Pargyline/pharmacology, Pyridines/pharmacology/toxicity, Pyridinium Compounds/pharmacology/toxicity, Rats, Tyrosine 3-Monooxygenase/analysis, MPTP, MPP, Heart, Noradrenaline, Adrenal catecholamines, Pargyline, Tyrosine hydroxylase