Effects of chronic noise or daily water restriction on the pituitary-adrenal axis in male rats

A. Armario
J.M. Castellanos
J. Balasch
42

Abstract

Pituitary-adrenal function was studied in male rats chronically stressed with noise as well as under water restriction regimen.Chronic noise did not modify either in vivo or in vitro corticoadrenal function.Daily water restriction decreased body weight and increased relative adrenal weight as well as the serum levels of ACTH and corticosterone.In vitro corticoadrenal responsiveness to ACTH was similar in control and water restricted rats.Thus, no evidence for increased adrenal sensitivity to ACTH in the pre-watering period was found in water restricted rats.

Keywords:
Noise, Water Deprivation, Adrenal Cortex/physiopathology, Adrenal Glands/pathology, Adrenocorticotropic Hormone/metabolism, Animals, Body Weight, Corticosterone/metabolism, Inbred Strains, Male, Organ Size, Physiological/physiopathology, Pituitary-Adrenal System/physiopathology, Rats, Stress, Adrenal cortex, Noise stress, Water restriction

Authors

A. Armario
J.M. Castellanos
J. Balasch


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