Hormonal influence on rat vas deferens responses induced by field stimulation

Abstract

The effect of castration and treatment with testosterone propionate (PT), estradiol benzoate (E2) and ciproterone acetate (CPA) on the responses of the vas deferens in rat has been studied.Castration produces a time-dependent decrease of the response amplitude.PT augments the response amplitude in normal rats and reverses the effect of castration.E2 augments the response amplitude in normal rats without modifying the castration effect.CPA does not change the response of the vas deferens.The results suggest that PT and E2 through possible different mechanisms, facilitate the transmission in rate vas deferens, whereas castration obstructs it.