The wake-sleep cycle in the cat following dorso-pontine lesions

Abstract

Modifications in total amount, frequency and duration of episodes of wakefulness, drowsiness, slow sleep and paradoxal sleep were examined in cats with small unilateral lesion in the locus coeruleus and/or neighbouring structures.Throughout a 8 week period, 24 h weekly records were obtained from each cat.Control group with lesions in the dorsomedial pontine area showed a noticeable stability in sleep-wakefulness cycle (SWC).Significant decrease of W (with shortening of episodes) occurred during the whole postlesion period in the group with lesions in the lateral vestibular nucleus.The group with small lesions restricted to the dorsal-intermediate part of RPO and RPC nuclei had only acute SWC modifications consisting of a decrease of W and increase of PS.Finally, small lesions in LC complex that encroached to a limited extent neighbouring structures produced a maintained decrease of W (with shortening of episodes) and increase of PS (due to a major number of episodes).Results suggest a different role of dorsopontine region from other pontine areas in SWC mechanisms and give support to the hypothesis of a permissive role of LC in PS mechanisms.