Estrogen binding in rat liver during pregnancy

Abstract

Estrogen binding in the liver of pregnant rats has been studied.When the results are expressed in pmol/mg of protein there is a marked decrease in relation to control rats on 12th or 21st days of gestation.In spite of the liver weight increase on day 21, however, the binding capacity for estrogens in the whole liver is still lower than in controls.It is suggested that the changes in rat liver estrogen receptors in late gestation cannot explain the action of estrogens on triglyceride rich lipoprotein synthesis and the consequent hypertriglyceridemia of late gestation.