Simultaneous diffusion of inositol and mannitol in the rat brain

C. Font
M. Garía-Campos
A.J. Hansen
E. Siemkowicz
A. Gjedde
47

Abstract

The diffusion of both inositol and mannitol has been determined simultaneously by the integral bolus method in rat brain.The permeability constant (Kin) of inositol averaged 0.27 +/- 0.02 ml X (100 g)-1 X min-1 or 4 X 10(-7) cm X s-1 at a cerebral capillary surface area of 100 cm2 x g-1.The permeability of mannitol was 0.08 +/- 0.01 ml X (100 g)-1.min-1 or 1 X 10(-7) cm X s-1.Neither glucose nor galactose affected the inositol permeability.Hypoglycemia increased somewhat the Km value for mannitol.The basal ganglia showed an increase Km for both substrates as compared with those obtained for cortex, temporal and parietal tissues.

Keywords:
Active, Animals, Basal Ganglia/metabolism, Biological Transport, Blood-Brain Barrier, Brain/metabolism, Cerebral Cortex/metabolism, Diffusion, Inbred Strains, Inositol/metabolism, Mannitol/metabolism, Parietal Lobe/metabolism, Rats, Temporal Lobe/metabolism

Authors

C. Font
M. Garía-Campos
A.J. Hansen
E. Siemkowicz
A. Gjedde


Metrics

Search GoogleScholar



Downloads

Download data is not yet available.

Section

Articles

Most read articles by the same author(s)