Antilipolytic activity in vitro of various analogs of nicotinic acid.Structure-activity relationship

Abstract

The antilipolytic activity of a series of N aryl-nicotinamides and of alpha picolinic acid, has been tested in vitro.Lipolysis was stimulated by epinephrine (20 micrograms/ml of incubation medium) using rat's epididymal adipose tissue slices.Only N(2-carboxy methyl phenyl) nicotinamide showed antilipolytic effect comparable to that of nicotinic acid at similar concentrations (2 X 10(-5) M).Picolinic acid (10(-4) M) showed no antilipolytic effect.These results, together with those of the literature, are discussed in regard to the relations between structure and antilipolytic activity.