Endogenous opioids in respiratory inhibition by laryngeal stimulation

Abstract

The reflex effect elicited by mechanical stimulation of the glottis has been studied in dogs.The three components of the response–sudden apnea, constriction of the glottis and bradycardia–were modified by naloxone, although not in the same degree.These results suggest the existence of opioid interneurons between laryngeal afferent fibers and central inspiratory neurons.