Effect of experimental subarachnoid hemorrhage on calcium incorporation and adrenergic innervation of the cerebral arteries of the cat

Abstract

The effect of experimental subarachnoid hemorrhage (SAH) on the adrenergic innervation and on the 45Ca2+ uptake of cat cerebral arteries was analyzed.Intracisternal injections of autologous blood reduced the noradrenaline content of perivascular nerve endings and 3H-noradrenaline uptake.These values returned to normal levels in a period of two weeks after SAH.The activity of dopamine-beta-hydroxylase was also reduced 3 and 7 days after SAH.Superior cervical gangliectomy and intracisternal injection of 6-hydroxydopamine also reduced these three parameters.The uptake of 45Ca2+ by arteries from animals submitted to SAH was greater than if the blood vessels were from untreated cats.Lantanum brought about a less 45Ca2+ displacement in the arterial segments from untreated animals than in those from cats after SAH.These results suggest that SAH induces a transient adrenergic denervation as well as changes in the membrane of smooth muscle cell which increase the quantity of Ca2+ bound to it.All these modifications might be involved in the cause of chronic cerebral vasospasm that appears after SAH.