Effect of calcium, glucose and trifluoroperazine on the carboxymethylation of proteins in pancreatic islets of rats

P. Mena; C. Barriga; J.E. Campillo

P. Mena

C. Barriga

J.E. Campillo

PDF (Spanish) (

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Published: 1988-06-01

Keywords:

Animals, Calcium/antagonists and inhibitors/pharmacology, Glucose/antagonists and inhibitors/pharmacology, Islets of Langerhans/metabolism, Male, Methanol/analysis, Methylation, Proteins/metabolism, Rats, Trifluoperazine/pharmacology

How to Cite

Effect of calcium, glucose and trifluoroperazine on the carboxymethylation of proteins in pancreatic islets of rats. (1988). Revista Española De Fisiología, 44(2), 211-214. https://revistas.unav.edu/index.php/ref/article/view/47043

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Abstract

In the isolated pancreatic islets incubated in vitro, carboxylmethylation increases following stimulation with 20 mM glucose.This increase is dependent on extracellular calcium concentration and is suppressed in the presence of trifluoperazine, a calmodulin inhibitor.In conclusion, the increase in carboxylmethylation induced by 20 mM glucose seems to be a calcium-dependent process and it is probably mediated by calmodulin.

Keywords:

Animals, Calcium/antagonists and inhibitors/pharmacology, Glucose/antagonists and inhibitors/pharmacology, Islets of Langerhans/metabolism, Male, Methanol/analysis, Methylation, Proteins/metabolism, Rats, Trifluoperazine/pharmacology