Effect of sympathetic stimulation on salivary secretion in submandibular gland in the rabbit stimulated by pilocarpine

M. Moreno
E. de Victoria
M.A. López
49

Abstract

The sympathetic stimulation under slow pilocarpine-induced flow conditions brought about a decrease in this flow rate that could be due to vasoconstriction, since such an effect was not observed after the administration of phentolamine (4 mg/kg i.v.).Contrariwise the injection of a beta-adrenergic blocking agent (propranolol 2-2.5 mg/kg i.v.) produced a decrease of the salivary flow rate that was even greater than in the control animals.These results suggest that the secretory effect in this gland and species is predominantly beta-adrenergic.The stated results are related to the changes observed in the blood outflow from the gland.

Keywords:
Salivation/drug effects, Adrenergic alpha-Antagonists/pharmacology, Adrenergic beta-Antagonists/pharmacology, Animals, Electric Stimulation, Phentolamine/pharmacology, Pilocarpine/pharmacology, Propranolol/pharmacology, Rabbits, Submandibular Gland/blood supply/innervation/metabolism, Vasoconstriction, Saliva, Sympathetic stimulation, Pilocarpine

Authors

M. Moreno
E. de Victoria
M.A. López


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