Nephrotoxicity of gentamicin and netilmicin in the rat. Quantification and qualification of glomeruli

Abstract

The application via i.v.jugular, in rats, of two fluorochromes (rhodamine 6GO and phosphine 3R) with a 10 min interval, allows the direct observation of nephronal corpuscles using an epifluorescent microscopical technique, as well as their eventual quantification and qualification into normal or semifunctional corpuscles.In rats previously treated by i.p.injection of gentamicin or netilmycin a decrease of the active nephronal population as well as an increase of the percentage of semifunctionality has been noticed.