Urinary triiodothyronine excretion

I. Orden
J. Pié
M.G. Juste
A. Giner
M.E. Gómez
J.F. Escanero
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Abstract

The purpose of this work was to estimate the 24 h urinary excretion of free and conjugated triiodotironine (T3) using a direct radioimmunoassay and enzyme hydrolysis.Mean urinary values of free and total T3 (mean +/- 1 SD) in euthyroid controls were 2074 +/- 673 and 2819 +/- 809 pmol/24 h respectively.In patients with hyperthyroidism, values of free hormone were about 4.2 times higher than the mean value of the euthyroid controls, and about one-third in patients with hypothyroidism.These results show this measurement to be useful as an indicator of thyroid function.Mean renal clearance of free T3 was 211.6 +/- 62.8 ml/min (mean +/- 1 SD) in euthyroid controls, 260.8 +/- 87.5 ml/ml in hyperthyroid patients and 229 +/- 98.7 ml/min in hypothyroid patients.The data show that T3 renal clearance is, in all cases, greater than glomerular filtration rate, suggesting tubular secretion of T3.

Keywords:
Adult, Aged, Circadian Rhythm, Female, Humans, Hyperthyroidism/blood/urine, Hypothyroidism/blood/urine, Kidney/metabolism, Male, Middle Aged, Triiodothyronine/blood/urine

Authors

I. Orden
J. Pié
M.G. Juste
A. Giner
M.E. Gómez
J.F. Escanero


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