A new proposal on the neural component of the control system of renal blood flow. Analysis using digital simulation

Abstract

A mathematical, non-lineal model for digital simulation of the neural control of blood renal flow (BRF) has been built, by using the system dynamic techniques.The control mechanisms considered have been the BRF regulation by means of a renal intrinsic system, and by means of an RNA-dependent system, being the latter a product of the peripheral sympathetic activity, of a tonic inhibitory system with a central origin, and of a system that inhibits this last one, which has an intrarenal origin.For the validation of the model, a spinal section has been simulated, and the data have been compared with the reported in the bibliography.The use of this model permits an approach to the study of different variables in physiological or pathological circumstances in man, especially of those involved in the neural regulation of the BFR, obviating the technical and ethical obstacles of experimental techniques and leading to the design of new animal trials.