Effect of indomethacin on the progesterone secretion of hysterectomized pseudopregnant rats

J.E. Sánchez-Criado
F. López
66

Abstract

The length of pseudopregnancy and the progesterone levels in rats pseudopregnant and hysterectomized on their 2nd day and injected daily with indomethacin (500 g/0.2 ml) from the 2nd to 10th day do not differ from those exhibited by oil treated rats.On the contrary, indomethacin treatment from 11th day on, results in both a lengthening of the diestrous phase and a delayed luteolysis.These findings point out to an extrauterine prostaglandin synthesis mechanism participating in the functional luteolysis in histerectomized pseudopregnant rats.

Keywords:
Hysterectomy, Pseudopregnancy, Animals, Female, Indomethacin/pharmacology, Luteolysis, Progesterone/metabolism, Rats

Authors

J.E. Sánchez-Criado
F. López


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