Effect of anoxia on saline diuresis and phlorhizin polyuria

Abstract

Glucosuria and polyuria caused by phlorizin in dogs are due to a diminution of tubular reabsorption which is not modified by anoxia, when the same dogs breathe oxygen at 5 %. The diminution of diuresis observed in the anoxia of these animals may be attributed to a decrease of glomerular filtration, anoxic diuresis, as in normal animals, not being observed.

In polyuria provoked by continuous endovenous injection of saline, the glomerular filtration increases at the same time as tubular reabsorption of water diminishes. When dogs with such polyuria are submitted to anoxia the tubular reabsorption of water is not modified. diuresis diminishing in the majority of the dogs, on account of the decrease of glomerular filtration.

In both groups of polyuric animals, the rebreathing- of normal air after anoxia gradually reestablishes the preanoxic diuresis and glomerular filtration rates.