Urinary excretion of histamine, in the rat, in relation to sex

E. Goñalons
A. Fraile
34

Abstract




The excretion of free histamine in adult rats previously hydrated was studied in the following groups of animals: 1) normal males; 2) normal females; 3-5) ovariectomized, tested after 7, 40 and 120 days; 6-7) sham operated females, tested after 7 and 120 days; 8) ovariectomized testosterone-treated, and 9) sham operated testosterone-treated females.


No changes in the rate of histamine ex­cretion were observed after seven days in ovariectomized and sham operated rats; but the urinary histamine was depressed in ovariectomized rats after 40 days from the operation. Testosterone propionate (0,5 mg/day during 5 days) significantly reduced the urinary excre­tion of free histamine in castrated and sham operated female rats, and the reduction was largest for the castrated animals; but in no case the urinary excretion of histamine was depressed to the male level.




Keywords:
Histamine, Animals, Castration, Female, Male, Rats, Testosterone/pharmacology, Urine

Authors

E. Goñalons
A. Fraile


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