Pharmacological protection against hypercapnic anoxemic anoxia caused by experimental submersion. The role of dipyridamole and of glucose

Abstract

An account is given of experiments designed to demonstrate certain «protective» actions of the drug 2.6 bis (diethanolamine) -.4.8-dipiperidine - pyrimidine (5.4-d)pyrimidine, initially classified as a specific coronary vasodilator, when confronted with a special type of massive anoxia: the hypercapnic anoxic anoxia which is produced by submersion. It is shown that, statistically, there are significant differences between the average resistance times of the mice which make up the problem lots (glucose, dipyramidol), and those of the control lot. The differences are of greater significance for the dipyramidol lots (P < 0.001) than for the glucose lots (P < 0.02).