Contribution to the study of anabolics

Abstract

A study has been made of the anabo­lic action (measured by the development in weight) of a derivative of testosterone. 17-a-methyl, 17-b-hydroxyl, androstan, 1-4-dien, 3-ona (Dianabol) on adult and new-born animals, castrated and subjec­ted to an administration of to mg of thiourea daily.

From the results obtained, two impor­tant facts stand out : 1. In no case were toxic lesions observed. 2. The results obtained in the animals subjected to the administration of thiourea were spec­tacularly favourable for those treated, and we observed not only a great in­crease in weight but also a marked re­gression in the thyroid histological le­sions.