Combined action of sulfamidic-insulin on glucemia in normal dogs

Abstract

The emergence of hypoglucemic sulfa­mides and their previous therapeutical applications, demonstrated that these pharmaceutical products were easily ca­pable of reducing the doses of insulin used to treat some diabetic patients. On this basis, the follow experiment was ca­rried out to study the effect of injecting normal dogs, jointly with insulin plus N - (4 - isopropoxibenzoil) - p - amino-benzol sulfamide.

The dogs were fed prior to the experi­ment and maintained under chloralosic anaestheses during the entire period of the experiment. Blood samples extracted from the dogs at 30, 60 and 90 minutes inter­vals during the experiment were analysed to determine its blood sugar content.

The doses utilized per kilogram of weight were as follows, 1 mg of sulfapro-xiline, and a quarter unit of insulin.

A comparative study was performed on injecting both these drugs separately, and jointly, the results so obtained can be apreciated on the figure.

The curve obtained using both these drugs jointly, if anything, proved that they had a less effective hypoglucemic ac­tion than that obtained using insulin alo­ne, with a decrease in capacity of the ani­mal in retuoning to normal.