Correlation between behavioural and electrophysiological effects of pyrithoxine in unrestrained cats and rabbits

Abstract

The mechanisms of action of the Pyrithoxine (Bis-3-hydroxymethyl-2 methylpyridyl- (5)-methyl-disulphide-dihdrochloride monohydrate) were study in chronic cats and rab­ bits. The experimental variables were: modifications of visual input as measured by evoked potentials techniques; electrical stimulation of the brain; aggressive behaviour; sexual behaviour; and the modifications of food intake.

It is concluded that Pyrithoxine induce an impairment of sexual behaviour in male rabbits, an increase in the threshold to electrical stimulation of amygdala and caudate nucleus and variations in the amplitude in the late response of the visual evoked po­ tentials.