Effects of sugars on the intestinal absorption of palmitic acid

J.M. Linazasoro
J.A. Sánchez-Martín
35

Abstract




When palmitic acid alone is given to rats, appears a small amount of radioactivity in the fat after 4 hours. When the palmitic acid is given in combination with glucose and galactose, the same amount of radioactivity is reached after 6 hours. When arabi­ nose is given instead of glucose or galactose, the results are similars to the palmitic control. Determination of radioactive fat in the liver and the adipose tissue cannot explain these differences between the radioactive levels in the plasmatic fat. However, it can be noticed when analysing the intestinal content of the radiactive fat, that in the first hours the recuperation is better when the palmitic acid is given with glucose or galactose.


The glucose or galactose are sugars that are actively absorbed (with transport ca­ pable of saturation), the ATP is necessary and acts as a limiting factor. The fatty acids in the intestinal wall react with the glycerol to form triglyceride, this reaction needs a Kinasa system with the coenzyme A and ATP which at the same time is a limiting factor of the reaction.


The sugars actively absorbed inhibit to some extent the absorption of the palmitic acid, being one of its possibilities for interfering with the disposabilities of ATP.




Keywords:
Intestinal Absorption, Adenosine Triphosphate/metabolism, Animals, Arabinose/pharmacology, Galactose/pharmacology, Glucose/pharmacology, Inbred Strains, Intestines/enzymology, Male, Palmitic Acids/metabolism, Rats

Authors

J.M. Linazasoro
J.A. Sánchez-Martín


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