Interaction of acetylcholine and amantadine on smooth and striated muscle fiber

Abstract

It was studied the interaction between amantadine and acetylcholine, employing different isolated organs, as uterus of rat, rabbit’s intestine, and frog rectus abdominis. Previous incubation with amantadine (6.5 X 10-1 M) in isolated uterus of normal or reserpinized rat, was obtained a acetylcholine curve dose-response, that showed a clear antagonism no-competitive. Similar results was happened with isolated rabbit's gut. Previous addition of amantadine (6.5X10_4M) on rectus abdominis of frog preparation, was also manifested a acetylcholine response blockade of no-competitive type.

From these results, it was deduced the existence of a clear antagonism no-competitive between amantadine and acetylcholine, with a little preceding agonism. By other hand without modification in the animals previously reserpinized.

These fenomenons can ould be explained by a possible blockade in ionic change induced by amantadine in muscle cell membrane.