Glycaemic response to intravenous tolbutamide in renal insufficiency

Abstract

Glycaemic Response to Intravenous Tolbutamide in Renal Insufficiency. Rev. esp. Fisiol., 30, 85-90. 1974.

Blood glucose response to intravenous tolbutamide has been studied in 15 normal subjects and 15 uremic patients with creatinine clearance less than 10 ml/min., and blood urea: 240.06±61.92 mg/100 mi. The test evaluation was made with the percen- tage fall of blood glucose from the basal level following tolbutamide. In uremic patients the blood glucose fall at 20 and 30 minutes following tolbutamide was less than in normáis, while at 60 minutes, the blood glucose fall was greater in uremics than in normáis. The greatest blood glucose fall was observed in uremics in comparison with the normáis. When uremic and normal subjects were studied in the same group, a significant correlation was obtained between the blood glucose fall at 20 and 60 minutes and the blood urea and creatinine levels. No correlation was observed when the uremics were studied alone. In conclusión: the blood glucose fall in response to tolbutamide in uremic patients is delayed, and permanent when it is established, and more pronounced than the normal. In our study, this pattern of response is correlated with the uremic condition, but not with the uremic levels.