Action of the antipsychotic drugs thiotixene and thioridazine on isolated mitochondria

Abstract

Thiotixene and thioridazine antipsychotic drugs produce a stimulation of mitochondrial respiration in state 3 and state 4 resulting in a complete respiratory control loss, only accompanied by slight alterations of oxidative phosphorylation. This effect may be of biological significance in the action mechanism of the drugs.