Inhibition of urease by hypoglycaemic drugs

Abstract
The effect of oral hypoglycaemic drugs (derived from sulphonylurea) on urease activity in the quantitative determination of urea has been studied. These compounds have been found to produce a competitive inhibition of enzyme activity with respect to substrate. Possible interference of these antidiabetic agents upon urea analysis is discussed.
Keywords:
Chlorpropamide/pharmacology, Tolbutamide/pharmacology, Urease/antagonists and inhibitors/blood
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