Motility of the rat ureter in vitro. Responses to cholinergic drugs

Abstract

The motility of the rat ureter has been studied in vitro. Sixteen per cent of isolated rat ureters present spontaneous motility which depends on the electrolytic composition of the nutritious solution employed. It seems that the cholinergic component in organs from animals previously reserpinized acts as stimulator since 56.6% of ureters with spontaneous motility was observed in vitro. The action or nicotine proves the existence of stimulating nicotinic receptors in the ureter wall. Acetylcholine acts as excitator as increases peristaltic frequency. Atropine, likewise, proves the existence of stimulating muscarinic receptors. Urine dilutions of 1:100 have also proves their ability for producing peristaltic motility in vitro.