Alpha-adrenergic blockers on ventricular automatism in rat heart

Abstract
The role of the alpha-adrenergic receptors in the genesis of cardiac arrhythmias induced in the isolated rat right ventricle has been studied. The administration of six alpha-adrenergic blocking agents (phenoxybenzamine, dibenamine, phentolamine, tolazoline, azapetine and SY-28) did not alter the automatism induced. Even when can not be excluded the existance of alpha-adrenergic receptors in the rat ventricle, it is clear that alpha-blocking drugs are ineffective to abolish the arrhythmias induced by an increase in the activity of the Purkinje fibers.
Keywords:
Ventricular Function, Adrenergic, Adrenergic beta-Antagonists/pharmacology, Animals, Anti-Arrhythmia Agents, Chemical, Female, Heart Conduction System/physiology, Heart Rate/drug effects, Male, Myocardial Contraction/drug effects, Purkinje Fibers/physiology, Rats, Receptors, Stimulation, alpha/drug effects
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