Effect of dextropoxyphene on oxidative phosphorylation in brain and liver of rat

I. Saiz; J.L. de Zárate; Z.A. Velasco

I. Saiz

J.L. de Zárate

Z.A. Velasco

PDF (Spanish) (

13)

Published: 1977-06-01

Keywords:

Animals, Brain/cytology/metabolism, Dextropropoxyphene/pharmacology, Liver/metabolism, Male, Mitochondria, Mitochondria/metabolism, Oxidative Phosphorylation/drug effects, Oxygen Consumption/drug effects, Phosphorus/metabolism, Rats

How to Cite

Effect of dextropoxyphene on oxidative phosphorylation in brain and liver of rat. (1977). Revista Española De Fisiología, 33(2), 109-112. https://revistas.unav.edu/index.php/ref/article/view/49553

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Abstract

Dextropropoxyphene hydrochloride increases significantly oxygen uptake in whole rat brain homogenates at concentrations of 10(-4), 10(-5), 10(-6) M when using sucrose 0.25 M pH 7.4 as incubation medium. If substrate and cofactors are added to the sucrose, this drug decreases oxygen uptake at 10(-3) M concentration in brain and liver rat homogenates, and it also decreases significantly the P:O quotient of mitochondria in both organs by uncoupling the oxidative phosphorylation.

Keywords:

Animals, Brain/cytology/metabolism, Dextropropoxyphene/pharmacology, Liver/metabolism, Male, Mitochondria, Mitochondria/metabolism, Oxidative Phosphorylation/drug effects, Oxygen Consumption/drug effects, Phosphorus/metabolism, Rats