Growth and differentiation of normal and vaccinia virus infected bone marrow stem cells

Abstract

The effect of vaccinia virus (v.v.) has been studied on the growth and differentiation of bone marrow stem cells, transferred between AKR syngenic mice and measured through the number of colonies on the surface of the spleens of host animals. A tem­ porary inhibition of the number of colonies has been found both when the v.v. is administered to the donor animal and when administered to the receptor animal. On the other hand, when the v.v. is administered simultaneously to the donor and to the receptor, there is no interference in the number of colonies.

These results suggest that v.v. interferes, by allogenic mechanism, with the growth and differentiation of bone marrow stem cells, when they are transferred in the above conditions.