Experimental study of shock traumatic. Influence of sustained arieriolar vasoconstriction and vasoconstrictor tone in the pathogenesis of shock

Abstract

A series of experiences are being reported concerning traumatic shock, performed by two different technics.

On one, experimental shock is prometed by means of an intracisternal injection of Potassium Phosphate soothing disolution. An initial hypertension phase is thus produced followed up by a progressive fall till collapse.

In others, initial hypertension phase is thus produced followed up by a progresive fall till collapse.

In others, initial hypertension phase is attained applying electric stimuli to the central extremity of both sciatics, sectioned during a minimum of two and one half hours time.

When interrupting the stimuli a steady pressure fall is also produced and the animal expires showing a typical shock.

It is observed, that analagous electric stimuli but of a much feeble intensity showing hypotensive responses, cas likewise lead to collapse.

By the interpretation of the experimental shock obtained with the two first technics, a decisive importance is awarded to persevering vasoconstriction, enabling the setting up of a tisular anoxious state resulting from ischemia. This gives place to a storage of the capillary distended methabolites and consequently a progressive shortening of the venous return, deducing that the very methabolite storage originator of the capillary enlargement, promotes the muscle’s sensitizing chemical afferents, thus emphasizing the vasoconstriction by reflex and this contributing factor strengthens ischemia effects.

The capillary enlargement usually appears very untimely as can be concluded from data showing deviation of acid-base (o base-acid) counterbalance towards acidosis. This being the reason to admit that in most cases, capillary enlargement is the most important agent in shock pathogenia for such kind of experiences.

The hemoconcentration on the contrary, seldom clearly appears in an early phase, and this is being specially observed on shock provoked by stimulus of somathic afferents.

It is deduced, that exhaustion of the vasoconstrictor center is not the loosening agent on the shock obtained through a Potassium Phosphate intracisternal injection. And only in rare cases of somathic afferent, stimuli might have an important assistante in the initial shock phase. The exhaustion of the vasoconstrictor center in the whole, does not seem to have any importance at all butonly in an advance phase when collapse can already be considered as irreversible.